DIPG Clinical Trials

Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma
Last Updated: 2019-12-03
Originally Posted: 2018-03-20

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Last Updated: 2019-12-02
Originally Posted: 2019-11-26

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
Last Updated: 2019-11-29
Originally Posted: 2015-02-09

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Last Updated: 2019-11-25
Originally Posted: 2018-10-09

Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Last Updated: 2019-11-21
Originally Posted: 2018-05-25

Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Last Updated: 2019-11-21
Originally Posted: 2018-11-02

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma
Last Updated: 2019-11-19
Originally Posted: 2018-09-17

Fimepinostat in Treating Brain Tumors in Children and Young Adults
Last Updated: 2019-11-15
Originally Posted: 2019-03-26

Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
Last Updated: 2019-11-14
Originally Posted: 2018-01-04

Volitinib in Treating Participants With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2019-11-07
Originally Posted: 2018-07-24

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Last Updated: 2019-10-17
Originally Posted: 2019-08-02

MTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2019-10-11
Originally Posted: 2018-06-12

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2019-09-25
Originally Posted: 2016-11-29

Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma
Last Updated: 2019-09-23
Originally Posted: 2016-02-22

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors
Last Updated: 2019-09-23
Originally Posted: 2017-12-05

ONC201 in Pediatric H3 K27M Gliomas
Last Updated: 2019-09-17
Originally Posted: 2018-01-23

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Last Updated: 2019-09-05
Originally Posted: 2015-12-27

Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Last Updated: 2019-09-03
Originally Posted: 2015-12-15

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Last Updated: 2019-08-22
Originally Posted: 2018-07-20

CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With Diffuse Intrinsic Pontine Glioma (DIPG)
Last Updated: 2019-08-07
Originally Posted: 2017-03-16

Oncolytic Adenovirus, DNX-2401, for Naive Diffuse Intrinsic Pontine Gliomas
Last Updated: 2019-08-06
Originally Posted: 2017-06-03

Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas
Last Updated: 2019-06-20
Originally Posted: 2018-10-03

Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma
Last Updated: 2019-05-28
Originally Posted: 2015-04-15

A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)
Last Updated: 2019-05-20
Originally Posted: 2017-11-22

Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2019-04-22
Originally Posted: 2017-04-19

Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors
Last Updated: 2019-04-17
Originally Posted: 2015-07-06

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Last Updated: 2019-03-27
Originally Posted: 2010-04-19

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2019-03-22
Originally Posted: 2013-04-16

Inform2 Nivent, An European Clinical Trial To Determine A Safe Dose And Signs Of Efficacy Of The Combination Treatment Of Novolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies*
Last Updated: 2019-03-18
Originally Posted: 2019-03-18

Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Last Updated: 2019-02-05
Originally Posted: 2013-06-19

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2018-08-07
Originally Posted: 2017-08-04

Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses
Last Updated: 2018-08-02
Originally Posted: 2018-05-14

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Last Updated: 2018-07-20
Originally Posted: 2014-08-29

Determining The Carbon-11 Labelled Erlotinib Brain Uptake In Diffuse Intrinsic Pontine Glioma Using Pet Imaging*
Last Updated: 2018-05-04
Originally Posted: 2018-05-04

Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma
Last Updated: 2018-02-14
Originally Posted: 2016-04-27

Study Of Cc-4047 In Patients With Brain Malignancies*
Last Updated: 2017-07-27
Originally Posted: 2017-07-27

An Investigational Immuno-therapy Study Of Nivolumab Monotherapy And Nivolumab In Combination With Ipilimumab In Pediatric Patients With High Grade Primary Cns Malignancies.*
Last Updated: 2017-04-17
Originally Posted: 2017-04-17

International Diffuse Intrinsic Pontine Glioma (DIPG) Registry and Repository
Last Updated: 2017-03-30
Originally Posted: 2017-03-08

Phase I Trial Of Dnx-2401 For Diffuse Intrinsic Pontine Glioma Newly Diagnosed In Pediatric Patients.*
Last Updated: 2016-08-18
Originally Posted: 2016-08-18

A Study Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors*
Last Updated: 2016-03-15
Originally Posted: 2016-03-15

Safety And Efficacy Of Cabazitaxel In Pediatric Patients With Refractory*
Last Updated: 2016-02-19
Originally Posted: 2016-02-19

Safety Study Of Dipg Treatment With Autologous Dendritic Cells Pulsed With Lysated Allegenic Tumor Lines*
Last Updated: 2016-01-13
Originally Posted: 2016-01-13

Abt-414 Alone Or Abt-414 Plus Temozolomide Versus Temozolomide Or Lomustine Alone In Subjects With Recurrent Glioblastoma.*
Last Updated: 2015-08-21
Originally Posted: 2015-08-21

Phase I Trial Of Afatinib In Pediatric Tumours*
Last Updated: 2015-02-09
Originally Posted: 2015-02-09

A Comprehensive And Targeted Therapy Approach In Pediatric Malignant Pontine Gliomas*
Last Updated: 2010-06-09
Originally Posted: 2010-06-09