DIPG / DMG Clinical Trials

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Trials current as of: 2024-07-16

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Clinical Trial
Sponsor
Pediatric Brain Tumor Consortium

Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
Last Updated: 2024-04-19
Originally Posted: 2024-01-24

Chulalongkorn University
University of California, San Francisco
Pediatric Brain Tumor Consortium
University of Miami
Meyer Children's Hospital IRCCS
SonALAsense, Inc.

xPedite: An Observational Study to Expedite DIPG and DMG Research
Last Updated: 2024-01-23
Originally Posted: 2023-11-20

xCures
Augusta University

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Last Updated: 2023-11-28
Originally Posted: 2022-10-14

Chimerix
Children's Oncology Group
Tata Memorial Centre
Mayo Clinic

GD2-CAR T Cells for Pediatric Brain Tumours
Last Updated: 2023-11-18
Originally Posted: 2022-03-28

Bambino Gesù Hospital and Research Institute

Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2023-11-18
Originally Posted: 2018-07-26

National Cancer Institute (NCI)
University of California, San Francisco
Chimerix

Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Last Updated: 2023-10-19
Originally Posted: 2022-08-15

Aminex Therapeutics, Inc.
Children's Hospital Medical Center, Cincinnati
Nationwide Children's Hospital
University of California, San Francisco

MCT for the Harvard/UCSF ROBIN Center
Last Updated: 2023-09-28
Originally Posted: 2023-08-21

Brigham and Women's Hospital

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Last Updated: 2023-09-28
Originally Posted: 2021-04-08

Wake Forest University Health Sciences
University of California, San Francisco

Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Last Updated: 2023-09-21
Originally Posted: 2018-08-29

Children's National Research Institute
Ann & Robert H Lurie Children's Hospital of Chicago

CAR T Cells to Target GD2 for DMG
Last Updated: 2023-09-11
Originally Posted: 2022-09-16

University College, London

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Last Updated: 2023-09-01
Originally Posted: 2019-09-23

Baylor College of Medicine
Nationwide Children's Hospital
National Institutes of Health Clinical Center (CC)
Stanford University

Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2023-08-02
Originally Posted: 2017-04-24

University of Calgary

Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-07-27
Originally Posted: 2021-02-11

Beijing Tiantan Hospital
Blueprint Medicines Corporation

B7-H3-CAR T Cells for Pediatric CNS Tumors
Last Updated: 2023-06-01
Originally Posted: 2023-04-28

St. Jude Children's Research Hospital
Bexion Pharmaceuticals, Inc.

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2023-04-13
Originally Posted: 2013-04-23

Northwell Health
European Organisation for Research and Treatment of Cancer - EORTC

A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
Last Updated: 2023-03-29
Originally Posted: 2021-03-22

German Cancer Research Center

A Drug-drug Interaction Study of Avapritinib and Midazolam
Last Updated: 2023-03-13
Originally Posted: 2021-06-01

Blueprint Medicines Corporation

FUS Etoposide for DMG - A Feasibility Study
Last Updated: 2023-03-09
Originally Posted: 2023-03-09

Columbia University

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-02-17
Originally Posted: 2016-12-14

University of Colorado, Denver
Children's National Research Institute

Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-02-08
Originally Posted: 2023-02-08

Capital Medical University
Capital Medical University

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Last Updated: 2023-01-30
Originally Posted: 2022-07-27

Gustave Roussy, Cancer Campus, Grand Paris
Nationwide Children's Hospital
Nationwide Children's Hospital
University of Calgary
Second Affiliated Hospital of Nanchang University
Weill Medical College of Cornell University
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2022-06-06
Originally Posted: 2017-08-09

University of Göttingen

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Last Updated: 2022-03-10
Originally Posted: 2020-02-11

Columbia University

Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Last Updated: 2021-11-15
Originally Posted: 2021-11-15

Ann & Robert H Lurie Children's Hospital of Chicago

Content courtesy of clinicaltrials.gov, clinicaltrialsregister.eu, and anzctr.org.au