DIPG / DMG Clinical Trials
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Trials current as of: 2023-10-04
Viewing 91 clinical trials across 153 countries:
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Last Updated: 2023-09-28
Originally Posted: 2021-10-28
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
Last Updated: 2023-09-27
Originally Posted: 2020-11-09
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Last Updated: 2023-09-26
Originally Posted: 2021-04-06
Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors
Last Updated: 2023-09-26
Originally Posted: 2021-12-14
Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma
Last Updated: 2023-09-26
Originally Posted: 2022-07-26
MCT for the Harvard/UCSF ROBIN Center
Last Updated: 2023-09-26
Originally Posted: 2023-08-03
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Last Updated: 2023-09-25
Originally Posted: 2022-09-27
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Last Updated: 2023-09-19
Originally Posted: 2018-08-28
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
Last Updated: 2023-09-11
Originally Posted: 2021-02-08
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Last Updated: 2023-09-07
Originally Posted: 2021-05-24
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Last Updated: 2023-09-06
Originally Posted: 2021-10-01
CAR T Cells to Target GD2 for DMG
Last Updated: 2023-09-06
Originally Posted: 2022-09-13
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Last Updated: 2023-08-30
Originally Posted: 2019-09-20
A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma
Last Updated: 2023-08-30
Originally Posted: 2020-01-22
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Last Updated: 2023-08-28
Originally Posted: 2018-07-20
Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis
Last Updated: 2023-08-24
Originally Posted: 2022-06-09
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Last Updated: 2023-08-23
Originally Posted: 2018-10-09
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Last Updated: 2023-08-23
Originally Posted: 2019-08-02
A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG
Last Updated: 2023-08-23
Originally Posted: 2021-10-11
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Last Updated: 2023-08-04
Originally Posted: 2019-12-10
CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Last Updated: 2023-08-01
Originally Posted: 2021-04-19
Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2023-07-31
Originally Posted: 2017-04-19
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Last Updated: 2023-07-27
Originally Posted: 2022-08-10
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-07-25
Originally Posted: 2021-02-03
Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children
Last Updated: 2023-07-24
Originally Posted: 2020-08-26
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
Last Updated: 2023-07-14
Originally Posted: 2018-01-04
A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
Last Updated: 2023-06-14
Originally Posted: 2021-02-09
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-05-30
Originally Posted: 2021-07-20
Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors
Last Updated: 2023-05-30
Originally Posted: 2023-03-23
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Last Updated: 2023-05-23
Originally Posted: 2021-02-17
Combination Therapy for the Treatment of Diffuse Midline Gliomas
Last Updated: 2023-05-11
Originally Posted: 2021-08-10
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2023-04-11
Originally Posted: 2013-04-16
ONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC 023)
Last Updated: 2023-04-04
Originally Posted: 2021-01-26
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Last Updated: 2023-03-29
Originally Posted: 2021-11-22
A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
Last Updated: 2023-03-27
Originally Posted: 2021-03-05
A Drug-drug Interaction Study of Avapritinib and Midazolam
Last Updated: 2023-03-09
Originally Posted: 2021-05-27
FUS Etoposide for DMG - A Feasibility Study
Last Updated: 2023-02-28
Originally Posted: 2023-02-06
International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2023-02-27
Originally Posted: 2023-02-27
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-02-16
Originally Posted: 2016-11-29
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Last Updated: 2023-02-08
Originally Posted: 2010-04-19
Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-01-29
Originally Posted: 2022-12-18
Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-01-29
Originally Posted: 2022-12-18
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Last Updated: 2023-01-27
Originally Posted: 2022-07-25
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Last Updated: 2023-01-18
Originally Posted: 2015-12-15
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors or Meningiomas Expressing SST2A
Last Updated: 2023-01-16
Originally Posted: 2022-02-07
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2023-01-13
Originally Posted: 2018-07-24
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Last Updated: 2023-01-05
Originally Posted: 2022-11-07
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Last Updated: 2023-01-04
Originally Posted: 2022-11-18
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
Last Updated: 2022-12-20
Originally Posted: 2021-11-04
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Last Updated: 2022-12-14
Originally Posted: 2019-11-26
HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
Last Updated: 2022-11-09
Originally Posted: 2020-11-17
Phase I Study Of Anti-gd2 Chimeric Antigen Receptor-expressing T Cells In Pediatric And Young Adult Patients Affected By Relapsed/refractory Central Nervous System Tumors
Last Updated: 2022-11-04
Originally Posted: 2022-11-04
International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Last Updated: 2022-09-08
Originally Posted: 2017-03-08
Combing a Deep Learning-Based Radiomics With Liquid Biopsy for Preoperative and Non-invasive Diagnosis of Glioma
Last Updated: 2022-09-08
Originally Posted: 2022-09-08
AflacST1901: Peds WP1066
Last Updated: 2022-07-24
Originally Posted: 2020-04-02
Phase Ib Clinical Trial To Assess The Safety, Tolerability, And Preliminary Efficacy Of Alocelyvir (mesenchymal Allogenic Cells + Icovir-5) In Children, Adolescent And Young Adults With Newly Diagnosed Diffuse Intrinsic Pointine Glioma (dipg) In Combination With Radiotherapy Or Medulloblastoma In Relapse/progression In Monotherapy.
Last Updated: 2022-07-11
Originally Posted: 2022-07-11
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Last Updated: 2022-07-06
Originally Posted: 2018-05-25
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2022-06-02
Originally Posted: 2017-08-04
A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-04-28
Originally Posted: 2020-01-07
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Last Updated: 2022-03-08
Originally Posted: 2020-02-07
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Last Updated: 2022-03-01
Originally Posted: 2020-09-01
A Phase 1/2, Single-arm Study To Evaluate The Safety, Pharmacokinetics, And Antitumor Activity Of Avapritinib In Pediatric Patients With Solid Tumors Dependent On Kit Or Pdgfra Signaling
Last Updated: 2022-01-26
Originally Posted: 2022-01-26
A Phase 1/2, Single-arm Study To Evaluate The Safety, Pharmacokinetics, And Antitumor Activity Of Avapritinib In Pediatric Patients With Solid Tumors Dependent On Kit Or Pdgfra Signaling
Last Updated: 2021-12-13
Originally Posted: 2021-12-13
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Last Updated: 2021-11-03
Originally Posted: 2021-11-03
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Last Updated: 2021-09-17
Originally Posted: 2015-12-27
Hypofractionated Radiotherapy for Recurrent DIPG
Last Updated: 2021-07-01
Originally Posted: 2019-02-12
Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
Last Updated: 2021-06-08
Originally Posted: 2011-12-29
Dipgen – Multicenter, Open Label Study Using Molecularly Determined Targeted Therapies In Children 3-18 Years Of Age With Dipg (diffuse Intrinsic Pontine Glioma- Dipg)
Last Updated: 2021-06-07
Originally Posted: 2021-06-07
International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2021-05-31
Originally Posted: 2021-05-31
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Last Updated: 2021-04-16
Originally Posted: 2013-06-19
Diagnostic And Clinical Value Of 64cucl2 In Hgg/dipg
Last Updated: 2021-04-16
Originally Posted: 2021-04-16
Adjuvant Dendritic Cell Immunotherapy Complementing Conventional Therapy For Pediatric Patients With High-grade Glioma And Diffuse Intrinsic Pontine Glioma
Last Updated: 2021-02-23
Originally Posted: 2021-02-23
Diffuse Brainstem Glioma Tumour Study: developing new treatment strategies for Diffuse Pontine Glioma
Last Updated: 2020-12-01
Originally Posted: 2012-10-31
Phase 2 Open Label Randomized Study Of Radiotherapy, Concomitant Nimotuzumab And Vinorelbine And Re-irradiation At Relapse Versus Radiotherapy And Multiple Elective Radiotherapy Courses With Concomitant Vinorelbine And Nimotuzumab For Newly Diagnosed Childhood And Adolescence Diffuse Intrinsic Pontine Glioma (dipg)
Last Updated: 2020-11-04
Originally Posted: 2020-11-04
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)
Last Updated: 2020-09-15
Originally Posted: 2019-12-02
Immune Modulatory DC Vaccine Against Brain Tumor
Last Updated: 2020-06-10
Originally Posted: 2019-04-11
International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2020-05-27
Originally Posted: 2016-11-21
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2020-03-31
Originally Posted: 2020-03-31
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2020-03-26
Originally Posted: 2020-03-26
Metro-pd1: A Phase I/ii Trial Evaluating Anti-pd1 (nivolumab) In
Combination With Metronomic Chemotherapy In Children And Teenagers
With Refractory /relapsing Solid Tumors
Last Updated: 2019-04-10
Originally Posted: 2019-04-10
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-03-18
Originally Posted: 2019-03-18
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-02-08
Originally Posted: 2019-02-08
A study to evaluate the safety,tolerability and pharmacokinetics of ACT001 in children with advanced brain and solid tumors
Last Updated: 2018-11-28
Originally Posted: 2018-11-05
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Last Updated: 2018-07-20
Originally Posted: 2014-08-29
A Phase 2 Clinical Study Of Pomalidomide (cc-4047) Monotherapy For Children And Young Adults With Recurrent Or Progressive Primary Brain Tumors.
Last Updated: 2018-01-30
Originally Posted: 2018-01-30
Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2017-08-01
Originally Posted: 2017-08-01
Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2016-06-22
Originally Posted: 2016-06-22
Phase Ib Clinical Trial On The Safety Of Immunotherapy With Autologous Dendritic Cells Primed With Lysate Allogeneic Tumor Lines In Patients With Diffuse Intrinsic Pontine Glioma ( Dipg )
Last Updated: 2016-01-13
Originally Posted: 2016-01-13
Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2015-09-16
Originally Posted: 2015-09-16