DIPG / DMG Clinical Trials
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Trials current as of: 2022-08-19
Viewing 80 clinical trials across 23 countries:
Eli Lilly and Company
A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors
Last Updated: 2022-08-17
Originally Posted: 2020-01-22
National Cancer Institute (NCI)
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Last Updated: 2022-08-17
Originally Posted: 2021-10-28
SonALAsense, Inc.
A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG
Last Updated: 2022-08-12
Originally Posted: 2021-10-11
Aminex Therapeutics, Inc.
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Last Updated: 2022-08-12
Originally Posted: 2022-08-10
Nationwide Children's Hospital
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
Last Updated: 2022-08-10
Originally Posted: 2020-11-09
Pfizer
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Last Updated: 2022-08-09
Originally Posted: 2018-10-09
University of California, San Francisco
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Last Updated: 2022-08-09
Originally Posted: 2018-11-02
Pediatric Brain Tumor Consortium
Phase I Study of APX005M in Pediatric CNS Tumors
Last Updated: 2022-08-08
Originally Posted: 2017-12-15
National Cancer Institute (NCI)
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2022-08-06
Originally Posted: 2018-07-24
Ann & Robert H Lurie Children's Hospital of Chicago
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Last Updated: 2022-08-04
Originally Posted: 2021-05-24
University of California, San Francisco
Combination Therapy for the Treatment of Diffuse Midline Gliomas
Last Updated: 2022-08-02
Originally Posted: 2021-08-10
Emory University
AflacST1901: Peds WP1066
Last Updated: 2022-07-24
Originally Posted: 2020-04-02
Blueprint Medicines Corporation
A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
Last Updated: 2022-07-19
Originally Posted: 2021-02-09
Nationwide Children's Hospital
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Last Updated: 2022-07-18
Originally Posted: 2018-07-20
Beijing Tiantan Hospital
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-07-18
Originally Posted: 2021-02-03
Augusta University
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Last Updated: 2022-07-15
Originally Posted: 2019-08-02
Fundación de Investigación Biomédica Hospital Niño Jesús
Phase Ib Clinical Trial To Assess The Safety, Tolerability, And Preliminary Efficacy Of Alocelyvir (mesenchymal Allogenic Cells + Icovir-5) In Children, Adolescent And Young Adults With Newly Diagnosed Diffuse Intrinsic Pointine Glioma (dipg) In Combination With Radiotherapy Or Medulloblastoma In Relapse/progression In Monotherapy.
Last Updated: 2022-07-11
Originally Posted: 2022-07-11
Pediatric Brain Tumor Consortium
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-07-08
Originally Posted: 2021-07-20
National Institutes of Health Clinical Center (CC)
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Last Updated: 2022-07-06
Originally Posted: 2018-05-25
University of California, San Francisco
Fimepinostat in Treating Brain Tumors in Children and Young Adults
Last Updated: 2022-07-05
Originally Posted: 2019-03-26
Stanford University
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Last Updated: 2022-06-22
Originally Posted: 2019-12-10
Bexion Pharmaceuticals, Inc.
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Last Updated: 2022-06-16
Originally Posted: 2021-02-17
University of Göttingen
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2022-06-02
Originally Posted: 2017-08-04
University of Calgary
HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
Last Updated: 2022-05-17
Originally Posted: 2020-11-17
University of California, San Francisco
Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors
Last Updated: 2022-05-09
Originally Posted: 2021-12-14
Baylor College of Medicine
T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors
Last Updated: 2022-05-03
Originally Posted: 2015-05-11
Seattle Children's Hospital
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Last Updated: 2022-05-02
Originally Posted: 2019-11-26
University of Florida
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
Last Updated: 2022-04-29
Originally Posted: 2018-01-04
Tata Memorial Centre
A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-04-28
Originally Posted: 2020-01-07
University of California, San Francisco
ONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC 023)
Last Updated: 2022-04-27
Originally Posted: 2021-01-26
Actuate Therapeutics Inc.
9-ING-41 in Pediatric Patients With Refractory Malignancies.
Last Updated: 2022-04-26
Originally Posted: 2020-01-20
Wake Forest University Health Sciences
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Last Updated: 2022-04-20
Originally Posted: 2021-04-06
Northwell Health
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2022-04-05
Originally Posted: 2013-04-16
Emory University
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Last Updated: 2022-04-01
Originally Posted: 2015-12-15
St. Jude Children's Research Hospital
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Last Updated: 2022-04-01
Originally Posted: 2018-02-09
Columbia University
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Last Updated: 2022-03-08
Originally Posted: 2020-02-07
Chimerix
ONC201 in Pediatric H3 K27M Gliomas
Last Updated: 2022-03-01
Originally Posted: 2018-01-23
Chimerix
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Last Updated: 2022-03-01
Originally Posted: 2020-09-01
Nationwide Children's Hospital
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
Last Updated: 2022-02-25
Originally Posted: 2021-11-04
Baylor College of Medicine
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Last Updated: 2022-02-07
Originally Posted: 2019-09-20
University of Colorado, Denver
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2022-01-31
Originally Posted: 2016-11-29
Mayo Clinic
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Last Updated: 2022-01-31
Originally Posted: 2021-10-01
Regeneron Pharmaceuticals
BLUEPRINT MEDICINES CORPORATION
A Phase 1/2, Single-arm Study To Evaluate The Safety, Pharmacokinetics, And Antitumor Activity Of Avapritinib In Pediatric Patients With Solid Tumors Dependent On Kit Or Pdgfra Signaling
Last Updated: 2022-01-26
Originally Posted: 2022-01-26
Oblato, Inc.
Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma
Last Updated: 2021-12-28
Originally Posted: 2020-05-06
University of Calgary
Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2021-12-14
Originally Posted: 2017-04-19
Cellectar Biosciences, Inc.
Dose Escalation Study of CLR 131 in Children, Adolescents, and Young Adults With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma
Last Updated: 2021-11-30
Originally Posted: 2018-03-20
Ann & Robert H Lurie Children's Hospital of Chicago
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Last Updated: 2021-11-03
Originally Posted: 2021-11-03
Children's National Research Institute
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Last Updated: 2021-11-01
Originally Posted: 2010-04-19
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Last Updated: 2021-09-17
Originally Posted: 2015-12-27
University Hospital, Antwerp
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma
Last Updated: 2021-09-13
Originally Posted: 2021-04-30
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses
Last Updated: 2021-09-03
Originally Posted: 2018-05-14
Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
Last Updated: 2021-08-21
Originally Posted: 2021-02-08
Children's National Research Institute
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Last Updated: 2021-07-15
Originally Posted: 2018-08-28
University of Cincinnati
Hypofractionated Radiotherapy for Recurrent DIPG
Last Updated: 2021-07-01
Originally Posted: 2019-02-12
Children's Hospital Medical Center, Cincinnati
International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Last Updated: 2021-06-18
Originally Posted: 2017-03-08
Y-mAbs Therapeutics
Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
Last Updated: 2021-06-08
Originally Posted: 2011-12-29
The Children's Memorial Health Institute
Dipgen – Multicenter, Open Label Study Using Molecularly Determined Targeted Therapies In Children 3-18 Years Of Age With Dipg (diffuse Intrinsic Pontine Glioma- Dipg)
Last Updated: 2021-06-07
Originally Posted: 2021-06-07
Georg-August-Universität Göttingen, Stiftung Öffentlichen Rechts, Universitätsmedizin Göttingen
International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2021-05-31
Originally Posted: 2021-05-31
Biotech Pharmaceutical Co., Ltd.
Nimotuzumab in Combined With Concurrent Radiochemotherapy in the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Last Updated: 2021-04-21
Originally Posted: 2020-08-26
Weill Medical College of Cornell University
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Last Updated: 2021-04-16
Originally Posted: 2013-06-19
ENTE OSPEDALIERO OSPEDALI GALLIERA
Diagnostic And Clinical Value Of 64cucl2 In Hgg/dipg
Last Updated: 2021-04-16
Originally Posted: 2021-04-16
Dr. David Ziegler
Diffuse Brainstem Glioma Tumour Study: developing new treatment strategies for Diffuse Pontine Glioma
Last Updated: 2020-12-01
Originally Posted: 2012-10-31
FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI"
Phase 2 Open Label Randomized Study Of Radiotherapy, Concomitant Nimotuzumab And Vinorelbine And Re-irradiation At Relapse Versus Radiotherapy And Multiple Elective Radiotherapy Courses With Concomitant Vinorelbine And Nimotuzumab For Newly Diagnosed Childhood And Adolescence Diffuse Intrinsic Pontine Glioma (dipg)
Last Updated: 2020-11-04
Originally Posted: 2020-11-04
Heidelberg University
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)
Last Updated: 2020-09-15
Originally Posted: 2019-12-02
Shenzhen Geno-Immune Medical Institute
Immune Modulatory DC Vaccine Against Brain Tumor
Last Updated: 2020-06-10
Originally Posted: 2019-04-11
Georg-August-Universität Göttingen, Stiftung Öffentlichen Rechts, Universitätsmedizin Göttingen
International Cooperative Phase Iii Trial Of The Hit-hgg Study Group For The Treatment Of High Grade Glioma, Diffuse Intrinsic Pontine Glioma, And Gliomatosis Cerebri In Children And Adolescents < 18 Years.
Last Updated: 2020-05-27
Originally Posted: 2016-11-21
Heidelberg University Hospital
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2020-03-31
Originally Posted: 2020-03-31
Heidelberg University Hospital
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2020-03-26
Originally Posted: 2020-03-26
Heidelberg University Hospital
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-03-18
Originally Posted: 2019-03-18
Heidelberg University Hospital
Inform2 Exploratory Multinational Phase I/ii Combination Study Of Nivolumab And Entinostat In Children And Adolescents With Refractory High-risk Malignancies
Last Updated: 2019-02-08
Originally Posted: 2019-02-08
Accendatech AU Pty Ltd
A study to evaluate the safety,tolerability and pharmacokinetics of ACT001 in children with advanced brain and solid tumors
Last Updated: 2018-11-28
Originally Posted: 2018-11-05
Gustave Roussy, Cancer Campus, Grand Paris
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Last Updated: 2018-07-20
Originally Posted: 2014-08-29
VU University Medical Center
11c-erlotinib Brain Uptake In Diffuse Intrinsic Pontine Glioma Imaged By Pet
Last Updated: 2018-05-04
Originally Posted: 2018-05-04
Celgene Corporation
A Phase 2 Clinical Study Of Pomalidomide (cc-4047) Monotherapy For Children And Young Adults With Recurrent Or Progressive Primary Brain Tumors.
Last Updated: 2018-01-30
Originally Posted: 2018-01-30
Gustave Roussy
Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2017-08-01
Originally Posted: 2017-08-01
Gustave Roussy
Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2016-06-22
Originally Posted: 2016-06-22
Fundació Sant Joan de Déu
Phase Ib Clinical Trial On The Safety Of Immunotherapy With Autologous Dendritic Cells Primed With Lysate Allogeneic Tumor Lines In Patients With Diffuse Intrinsic Pontine Glioma ( Dipg )
Last Updated: 2016-01-13
Originally Posted: 2016-01-13
Gustave Roussy
Biological Medicine For Diffuse Intrinsic Pontine Glioma (dipg) Eradication
Last Updated: 2015-09-16
Originally Posted: 2015-09-16
VU University Medical Center
A Comprehensive And Targeted Therapy Approach In Pediatric Malignant Pontine Gliomas
Last Updated: 2010-06-09
Originally Posted: 2010-06-09