DIPG / DMG Clinical Trials
DIPG and DMG are complex diagnoses, and treatment options continue to evolve. Clinical trials may be one option to consider as you explore what comes next.
We've provided a pre-filtered search through www.clinicaltrials.gov to help you find trials that are currently recruiting or active for DIPG and DMG.
If you have questions about finding clinical trials that are available, please reach out and we are more than happy to help.
Please Note: The most accurate and up-to-date trial information can be found by accessing ClinicalTrials.gov using the link above.
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Originally Posted: 2024-06-13
Study of Ribociclib and Everolimus in HGG and DIPG
Originally Posted: 2023-05-04
Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG
Originally Posted: 2017-01-27
Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
Originally Posted: 2024-01-24
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
Originally Posted: 2020-07-24
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration
Originally Posted: 2019-12-17
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
Originally Posted: 2023-07-21
CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
Originally Posted: 2024-03-12
Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).
Originally Posted: 2024-03-07
A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG
Originally Posted: 2021-11-17
xPedite: An Observational Study to Expedite DIPG and DMG Research
Originally Posted: 2023-11-20
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Originally Posted: 2019-08-08
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Originally Posted: 2021-10-29
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Originally Posted: 2022-10-14
CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Originally Posted: 2021-05-04
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Originally Posted: 2018-10-17
A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
Originally Posted: 2020-01-31
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Originally Posted: 2021-10-14
GD2-CAR T Cells for Pediatric Brain Tumours
Originally Posted: 2022-03-28
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Originally Posted: 2018-07-26
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
Originally Posted: 2015-02-10
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Originally Posted: 2022-11-14
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Originally Posted: 2022-11-29
ONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC 023)
Originally Posted: 2021-02-01
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Originally Posted: 2020-09-09
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Originally Posted: 2022-08-15
A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors
Originally Posted: 2020-01-23
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Originally Posted: 2021-07-27
International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Originally Posted: 2017-04-05
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
Originally Posted: 2020-12-07
Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma
Originally Posted: 2022-07-28
MCT for the Harvard/UCSF ROBIN Center
Originally Posted: 2023-08-21
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Originally Posted: 2021-04-08
Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors
Originally Posted: 2021-12-27
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Originally Posted: 2018-08-29
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
Originally Posted: 2021-02-17
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Originally Posted: 2021-06-29
CAR T Cells to Target GD2 for DMG
Originally Posted: 2022-09-16
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Originally Posted: 2019-09-23
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Originally Posted: 2018-07-30
Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis
Originally Posted: 2022-06-10
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Originally Posted: 2019-12-12
Re-Irradiation of Progressive or Recurrent DIPG
Originally Posted: 2017-04-24
Nimotuzumab in Combined With Concurrent Radiochemotherapy in the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Originally Posted: 2020-08-31
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Originally Posted: 2021-02-11
Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors
Originally Posted: 2023-03-15
A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
Originally Posted: 2021-02-26
B7-H3-CAR T Cells for Pediatric CNS Tumors
Originally Posted: 2023-04-28
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Originally Posted: 2021-02-25
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Originally Posted: 2013-04-23
Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Originally Posted: 2022-02-28
A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
Originally Posted: 2021-03-22
A Drug-drug Interaction Study of Avapritinib and Midazolam
Originally Posted: 2021-06-01
FUS Etoposide for DMG - A Feasibility Study
Originally Posted: 2023-03-09
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Originally Posted: 2016-12-14
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Originally Posted: 2010-04-20
Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
Originally Posted: 2023-02-08
Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
Originally Posted: 2023-02-08
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Originally Posted: 2022-07-27
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors or Meningiomas Expressing SST2A
Originally Posted: 2022-03-14
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
Originally Posted: 2021-11-26
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Originally Posted: 2019-12-04
HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
Originally Posted: 2020-12-17
Combing a Deep Learning-Based Radiomics With Liquid Biopsy for Preoperative and Non-invasive Diagnosis of Glioma
Originally Posted: 2022-09-12
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Originally Posted: 2013-06-24
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Originally Posted: 2015-12-31
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Originally Posted: 2017-08-09
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Originally Posted: 2020-02-11
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Originally Posted: 2021-11-15