DIPG / DMG Clinical Trials

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG
Last Updated: 2024-06-19
Originally Posted: 2017-01-27

Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
Last Updated: 2024-04-19
Originally Posted: 2024-01-24

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
Last Updated: 2024-04-17
Originally Posted: 2020-07-24

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration
Last Updated: 2024-04-05
Originally Posted: 2019-12-17

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
Last Updated: 2024-03-15
Originally Posted: 2023-07-21

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
Last Updated: 2024-03-12
Originally Posted: 2024-03-12

Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).
Last Updated: 2024-03-07
Originally Posted: 2024-03-07

A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2 in Patients With DIPG
Last Updated: 2024-01-31
Originally Posted: 2021-11-17

xPedite: An Observational Study to Expedite DIPG and DMG Research
Last Updated: 2024-01-23
Originally Posted: 2023-11-20

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Last Updated: 2023-12-19
Originally Posted: 2019-08-08

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Last Updated: 2023-12-04
Originally Posted: 2021-10-29

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Last Updated: 2023-11-28
Originally Posted: 2022-10-14

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Last Updated: 2023-11-24
Originally Posted: 2021-05-04

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Last Updated: 2023-11-22
Originally Posted: 2018-10-17

A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-11-22
Originally Posted: 2020-01-31

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
Last Updated: 2023-11-21
Originally Posted: 2021-10-14

GD2-CAR T Cells for Pediatric Brain Tumours
Last Updated: 2023-11-18
Originally Posted: 2022-03-28

Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Last Updated: 2023-11-18
Originally Posted: 2018-07-26

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
Last Updated: 2023-11-07
Originally Posted: 2015-02-10

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Last Updated: 2023-11-03
Originally Posted: 2022-11-14

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Last Updated: 2023-11-03
Originally Posted: 2022-11-29

ONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC 023)
Last Updated: 2023-10-27
Originally Posted: 2021-02-01

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Last Updated: 2023-10-26
Originally Posted: 2020-09-09

Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Last Updated: 2023-10-19
Originally Posted: 2022-08-15

A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors
Last Updated: 2023-10-11
Originally Posted: 2020-01-23

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-10-10
Originally Posted: 2021-07-27

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Last Updated: 2023-10-04
Originally Posted: 2017-04-05

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
Last Updated: 2023-09-29
Originally Posted: 2020-12-07

Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma
Last Updated: 2023-09-28
Originally Posted: 2022-07-28

MCT for the Harvard/UCSF ROBIN Center
Last Updated: 2023-09-28
Originally Posted: 2023-08-21

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Last Updated: 2023-09-28
Originally Posted: 2021-04-08

Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors
Last Updated: 2023-09-28
Originally Posted: 2021-12-27

Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Last Updated: 2023-09-21
Originally Posted: 2018-08-29

Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
Last Updated: 2023-09-13
Originally Posted: 2021-02-17

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
Last Updated: 2023-09-11
Originally Posted: 2021-06-29

CAR T Cells to Target GD2 for DMG
Last Updated: 2023-09-11
Originally Posted: 2022-09-16

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Last Updated: 2023-09-01
Originally Posted: 2019-09-23

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Last Updated: 2023-08-29
Originally Posted: 2018-07-30

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis
Last Updated: 2023-08-25
Originally Posted: 2022-06-10

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)
Last Updated: 2023-08-08
Originally Posted: 2019-12-12

Re-Irradiation of Progressive or Recurrent DIPG
Last Updated: 2023-08-02
Originally Posted: 2017-04-24

Nimotuzumab in Combined With Concurrent Radiochemotherapy in the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Last Updated: 2023-07-27
Originally Posted: 2020-08-31

Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-07-27
Originally Posted: 2021-02-11

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors
Last Updated: 2023-06-29
Originally Posted: 2023-03-15

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
Last Updated: 2023-06-15
Originally Posted: 2021-02-26

B7-H3-CAR T Cells for Pediatric CNS Tumors
Last Updated: 2023-06-01
Originally Posted: 2023-04-28

A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Last Updated: 2023-05-24
Originally Posted: 2021-02-25

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Last Updated: 2023-04-13
Originally Posted: 2013-04-23

Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Last Updated: 2023-03-30
Originally Posted: 2022-02-28

A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
Last Updated: 2023-03-29
Originally Posted: 2021-03-22

A Drug-drug Interaction Study of Avapritinib and Midazolam
Last Updated: 2023-03-13
Originally Posted: 2021-06-01

FUS Etoposide for DMG - A Feasibility Study
Last Updated: 2023-03-09
Originally Posted: 2023-03-09

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-02-17
Originally Posted: 2016-12-14

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Last Updated: 2023-02-10
Originally Posted: 2010-04-20

Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-02-08
Originally Posted: 2023-02-08

Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
Last Updated: 2023-02-08
Originally Posted: 2023-02-08

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Last Updated: 2023-01-30
Originally Posted: 2022-07-27

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors or Meningiomas Expressing SST2A
Last Updated: 2023-01-18
Originally Posted: 2022-03-14

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
Last Updated: 2022-12-21
Originally Posted: 2021-11-26

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Last Updated: 2022-12-19
Originally Posted: 2019-12-04

HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers
Last Updated: 2022-11-10
Originally Posted: 2020-12-17

Combing a Deep Learning-Based Radiomics With Liquid Biopsy for Preoperative and Non-invasive Diagnosis of Glioma
Last Updated: 2022-09-12
Originally Posted: 2022-09-12

Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
Last Updated: 2022-08-09
Originally Posted: 2013-06-24

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors
Last Updated: 2022-06-23
Originally Posted: 2015-12-31

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Last Updated: 2022-06-06
Originally Posted: 2017-08-09

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Last Updated: 2022-03-10
Originally Posted: 2020-02-11

Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Last Updated: 2021-11-15
Originally Posted: 2021-11-15